Passive skill trees and ascendancy choices amplify skill gem effectiveness, providing bonuses such as increased damage, reduced cooldowns, or enhanced effects for specific gem types. Players can design their trees around their preferred gems, creating characters that excel in certain damage types, elemental interactions, or specialized combat roles. This synergy between passive skills, active gems, and support modifiers is what makes Path of Exile 2’s system uniquely rewarding for those willing to invest time in planning and experimentation.Endgame challenges test skill gem optimization to the fullest. Maps, league mechanics, and powerful bosses require players to fully understand the strengths and limitations of their gem setups. Adapting to environmental modifiers, enemy resistances, and unique encounters ensures that skill gem mastery is a continuous process of refinement and adaptation.