When you are chasing that one perfect drop in Borderlands, you do not want to end up with a setup that hits like a truck but folds the second someone looks at you funny, or one that can take a beating but barely scratches enemies. Anyone who has spent a night farming knows the pain. You are either wiping bosses in seconds but getting knocked out by a random Skag pup, or you are tanking every hit yet taking forever to clear a single mob. The best farming build hits that balance, mixing heavy firepower with staying power so you can run the field without worrying about cheap deaths. It is about being efficient, plowing through content so your loot-per-hour stays high, and that is where smart combinations of skills and gear—and a bit of Borderlands 4 Cash—can make all the difference.
 First thing to lock down is your ability to stay standing. You will want to invest into skills that push up shield capacity and recharge speed, but pay close attention to recharge delay. Small numbers here mean you are back in the fight faster. Any perks that cut incoming damage or give health back after your action skill are gold. 
For gear, go for a high-capacity shield with snappy recharge. Anointments that trigger shield regen right after popping your action skill are pure synergy—they mean every time you go on the offensive, your defense comes back online too. This loop makes sure you can push forward without constantly ducking for cover.
 Now, you do not need to surrender damage for toughness. The smart play is to snag skills that boost weapon or elemental damage without pulling from defense stats. There is a sweet trick with abilities that buff your damage while shields are full or that drop explosions on hits. Splash damage is the go-to for farming—it clears rooms quicker than precise single-target builds. Rocket launchers, grenade-heavy SMGs, or boom-happy assault rifles are perfect if paired with perks that stretch that splash radius. When your class mod feeds into these skills, all your explosions hit harder and wider, turning you into the kind of roam-and-clear machine that makes farming feel easy.
 Everything works best when your loadout runs like a single unit. Your kitted splash weapon, your quick-regen shield, your skill-empowering class mod—they should all sync. That last slot, your artifact, can be where you tighten the loop. Aim for one that bulks up your area-of-effect hits or spikes your damage after each kill. 
Artifacts that add elemental zones when you slide can sneak in more passive damage as you move, helping you chain kills without slowing down. When every piece of gear is boosting something else, you have built a cycle of damage and defense that just keeps going, letting you farm for hours—and if you ever want to speed up the grind, you can always Borderlands 4 Items for sale.