For extreme fatigue, the best approach depends on the underlying cause. Conditions like chronic fatigue syndrome, sleep apnea, narcolepsy, or multiple sclerosis often require targeted treatment. In some cases, doctors may prescribe Modalert 200, a wakefulness-promoting medication, to help reduce daytime sleepiness and improve alertness. Modalert 200 can enhance focus and mental energy but isn’t a cure and should not replace proper sleep or medical care. A full evaluation, healthy sleep habits, stress management, balanced nutrition, and regular exercise are essential. Always consult a healthcare provider to find the safest and most effective solution for extreme fatigue.